A controlled trial of nandrolone decanoate in the treatment of rheumatoid arthritis in postmenopausal women.
نویسندگان
چکیده
To determine whether an anabolic steroid had any benefit in the treatment of rheumatoid arthritis 47 patients entered a parallel group study. Twenty four received nandrolone decanoate 50 mg intramuscularly every third week for two years and 23 patients received no anabolic steroids. Other therapy was unaltered. Patients attended for clinical and biochemical assessments as well as the objective assessments of elementary body composition by in vivo neutron activation analysis and measurement of the mineral content of the distal femur by single photon absorptiometry on five occasions. A modest clinical deterioration (except for grip strength) was seen in both groups. No significant changes in calcium or alkaline phosphatase were seen. There was no significant change in total body calcium, total body phosphorus, body weight, or bone index/bone width measurements in either group. Significant increases occurred in total body nitrogen, total body potassium, haemoglobin, and packed cell volume (by six months) in the group treated with nandrolone decanoate. Comparison of 10 patients in the group treated with nandrolone decanoate also receiving oral steroid therapy with 14 patients in this group not receiving oral steroid therapy showed no significant differences. The main side effect of nandrolone decanoate was hoarseness. No radiological changes were seen. Nandrolone decanoate, in a dose that produces a significant anabolic effect, has no demonstrable action on bone metabolism in rheumatoid arthritis but may improve the chronic anaemia by six months.
منابع مشابه
Efficacy of Nandrolone Decanoate in Treating Rheumatoid Cachexia in Male Rheumatoid Arthritis Patients
متن کامل
Risk of infection in postmenopausal women with rheumatoid arthritis and osteoporosis taking denosumab and bDMARDS
Background: There is no clear consensus regarding the potential of denosumab for increasing the risk of infection in patients who concurrently receive biologic disease-modifying anti-rheumatic drugs (bDMARDs). In this study, we compared the rate of infection in postmenopausal women with rheumatoid arthritis who received concurrent bDMARDs and denosumab with those who received bDMARDs alone. ...
متن کاملEffects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial
Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid ar...
متن کاملشیوع پوکی استخوان و عوامل موثر بر آن در زنان یائسه مبتلا به آرتریت روماتویید: گزارش کوتاهشیوع پوکی استخوان و عوامل موثر بر آن در زنان یائسه مبتلا به آرتریت روماتویید: گزارش کوتاه
Background: Low bone mass is a serious health problem mostly seen in postmeno-pausal women with rheumatoid arthritis. The purpose of this study was to determine the prevalence of osteoporosis and some related risk factors in postmenopausal women with rheumatoid arthritis.Methods: The data for this descriptive analytical study was extracted from the medical records of 98 postmenopausal women wit...
متن کاملProtective Effect of Human Menopausal Gonadotropins on Rat Ovarian Structure Following Use of Nandrolone Decanoate: From a Histological Standpoint
Background and Aim: Nandrolone decanoate is known as one of the most destructive environmental factors in the reproductive system in men and women. In this study, we assessed the protective effect of gonadotropins (hMG) on histological changes of rat ovarian structure. Materials and Methods: 50 female rats were divided into 5 groups, including control, nandrolone decanoate (ND), hMG, ND + hMG, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 46 3 شماره
صفحات -
تاریخ انتشار 1987